Human / animal clinical trials related to NMN
There are a large number of literatures in various places that show the anti-aging effect of NMN. We hope to make an integration so that everyone can understand this technology product better. From the raw materials of 10,000 yuan in the past, it has now begun to be popularized. NMN is no longer a plaything for celebrities, but It can really change everyone's daily supplements.
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August 2022 Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes
August 2022 Nicotinamide mononucleotide ameliorates DNFB-induced atopic dermatitis-like symptoms in mice by blocking activation of ROS-mediated JAK2/STAT5 signaling pathway
July 2022Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE
July 2022Combination of nicotinamide mononucleotide and troxerutin induces full protection against doxorubicin-induced cardiotoxicity by modulating mitochondrial biogenesis and inflammatory response
July 2022Administration of nicotinamide mononucleotide improves oocyte quality of obese mice
July 2022Nicotinamide Mononucleotide and Coenzyme Q10 Protects Fibroblast Senescence Induced by Particulate Matter Preconditioned Mast Cells
June 2022 Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice
June 2022Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis
June 2022 Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis
June 2022 Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment
June 2022 Nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stress
June 2022 Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury
June 2022 Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells
June 2022Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling
May 2022 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling
May 2022Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver
May 2022 Distribution of Nicotinamide Mononucleotide After Intravenous Injection in Normal and Ischemic Stroke Mice
May 2022Nicotinamide mononucleotide ameliorates acute lung injury by inducing mitonuclear protein imbalance and activating the UPR mt
May 2022 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling
April 2022NAD + Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy
April 2022 NAD +-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice
April 2022Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency
April 2022 Treatment of SARS-CoV-2-induced pneumonia with NAD + and NMN in two mouse models
April 2022 Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects
April 2022 The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions
April 2022NAD + Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy
April 2022Nicotinamide mononucleotide induces heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress
April 2022 Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes
April 2022 NAD+ ameliorates endotoxin-induced acute kidney injury in a sirtuin1 – dependent manner via GSK-3 β /Nrf2 signaling pathway
April 2022 Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment
April 2022 Intestinal Epithelial NAD+ Biosynthesis Regulates GLP-1 Production and Postprandial Glucose Metabolism in Mice
April 2022 NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages
April 2022NAD supplementation improves mitochondrial performance of cardiolipin mutants
March 2022 Antioxidant effect of nicotinamide mononucleotide in tendinopathy
March 2022 Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during aging
March 2022 Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy
March 2022 Nicotinamide mononucleotide increases cell viability and restores tight junctions in high-glucose-treated human corneal epithelial cells via the SIRT1/Nrf2/HO-1 pathway
February 2022Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study
February 2022 PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
January 2022 Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns
January 2022NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury
December 2021Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic-Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats
November 2021Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
November 2021The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase
November 2021NAD + Metabolism in Cardiac Health, Aging, and Disease
November 2021 Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice
October 2021 β -Nicotinamide Mononucleotide (NMN) Administered by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice
October 2021Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?
July 2021 NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota
July 2021Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments
July 2021 Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study
June 2021 The new insight into extracellular NAD + degradation—the contribution of CD38 and CD73 in calcific aortic valve disease
June 2021 Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy
June 2021Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
June 2021 Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation
June 2021 Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice
May 2021Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells
April 2021 Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats
March 2021Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway
March 2021Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence
February 2021Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether
February 2021Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System
January 2021 Generation and assessment of high-quality mouse oocytes and embryos following nicotinamide mononucleotide administration
January 2021 Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE 2 degradation
December 2020 Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
In December 2020 , NMN reduced the chance and severity of novel coronavirus infection by improving mitochondrial dysfunction
In November 2020 , NMN can reverse the loss of protein homeostasis and reduce kidney aging in animal experiments
November 2020NMN can become a new generation of treatment to prevent liver fibrosis in animals
October 2020 NMN can effectively enhance the healing and neurological rehabilitation of corneal epithelial damage in diabetic animals
In October 2020 , NMN can reverse the systolic dysfunction of the aged heart in animal experiments
August 2020 NMN can reverse cardiovascular endothelial cell dysfunction in animals
In August 2020 , NMN can reverse oocyte aging in animals and theoretically improve human female infertility
In August 2020 , NMN can effectively inhibit and reduce DNA mutations in oocytes in animals, and it is expected to become one of the female infertility treatment options.
In July 2020 , NMN can treat osteoporosis caused by taking steroids in animals
July 2020 NMN can effectively reduce brain cell damage caused by severe hypoglycemia in animals
July 2020 NMN may be effective in human age-related macular degeneration
June 2020 To explore the possibility of NMN in the treatment of neuromedical diseases
In May 2020 , NMN has a preventive effect on animal brain amnesia and dementia due to diabetes
April 2020 Explore the feasibility of NMN for the treatment of various diseases
April 2020NMN can effectively reduce the apoptosis of corneal endothelial cells induced by UVB irradiation
April 2020 NMN can promote neurovascular regeneration in aged animals
April 2020 NMN can reduce metabolic diseases caused by maternal overweight in animals
In March 2020 , NMN can effectively improve intracranial hemorrhage in animals and protect brain tissue
March 2020 NMN can treat acute brain injury and neurodegenerative diseases in animals
February 2020 NMN is effective in treating depression in animals
Feb 2020 NMN rejuvenates oocyte mass in aging animals leading to restoration of fertility
February 2020 NMN can effectively prevent corneal endothelial cell apoptosis in animals
February 2020 NMN rescues neurovascular function, increases cerebral blood flow and improves performance on cognitive tasks in animals
January 2020 NMN can improve cardiomyocyte hypertrophy caused by excessive stress in animals
The following are ongoing / researched and reported human clinical trials :
In November 2019 , there were no adverse reactions after taking NMN in human clinical trials
May 2019 Summarize the efficacy of NMN on metabolic diseases and discuss its human clinical trials
In January 2019 , discuss the therapeutic effects of NMN on heart protection , diabetes prevention , cognitive impairment , and complications caused by obesity
In July 2017 , the effect of human taking NMN on cardiovascular and metabolic diseases
In March 2016 , Keio University in Japan and Washington University in St. Louis started the first phase of human clinical trials on NMN
Many doctors and scientists around the world are beginning to conduct human clinical research on NMN. From the analysis of many known animal clinical effects, scientists believe that NMN is optimistic and positive for human health maintenance and anti-aging effects. It is believed that the time for human clinical results to be available is not far away.
The author is a registered doctor, and I firmly believe that NMN can help human health and delay human aging. My family and I have been taking NMN daily for quite some time. I also recommend that everyone start taking it today.
Application of NMN in animal chronic alcoholic liver disease in December 2019
December 2019NMN can effectively reduce memory loss caused by aging animals
December 2019 NMN has curative effect on muscle aging in animals
In October 2019 , NMN has curative effect on acute myocardial ischemia in animals
In October 2019 , NMN significantly helped the regeneration of cerebrovascular cells in aged animals
In August 2019 , NMN can effectively reduce animal vascular aging
In August 2019 , NMN can reduce corneal epidermal cell apoptosis in animals
August 2019 The effect of NMN on mitochondria in animals can improve pathophysiological stress disorders
June 2019 NMN can effectively maintain telomere length and have curative effect on liver fibrosis
May 2019 NMN is helpful for animal cerebrovascular diseases and can improve brain power
In April 2019 , NMN was confirmed to be helpful in animal diabetic nephropathy
In April 2019 , NMN enhanced the curative effect of mesenchymal stem cells on bone hyperplasia in animals
In March 2019 , it was suggested that NMN should be listed as one of the rigorous programs for the treatment of human cardiovascular disease aging
March 2019 NMN may be effective in treating osteoporosis in animals or humans
March 2019 NMN may be a future effective treatment for diabetic nephropathy in animals
March 2019 Discuss the principle of NMN anti-aging and ischemia treatment
In February 2019 , NMN has curative effect on animal mitochondrial diseases
January 2019 NMN has great potential to treat neurodegenerative diseases
In November 2018 , NMN increases the cognitive ability of animal brains
In October 2018 , NMN can effectively improve the osteoporosis caused by aluminum in animals
October 2018 NMN can effectively protect the degeneration of intervertebral discs in animals
September 2018 NMN greatly increases animals' chances of surviving hemorrhagic shock
August 2018 NMN has a protective effect on the heart of animals
In June 2018 , NMN can effectively improve the aging of animal retinal epidermal tissue
In March 2018 , NMN can effectively increase the blood flow of various organs in animals
December 2017 NMN/Nicotinamide Riboside may be effective for human cognitive impairment ( commonly known as Alzheimer's disease )
In November 2017 , NMN has curative effect on animal glucose intolerance and fat loss
In November 2017 , NMN has curative effect on animal diabetic nephropathy
In November 2017 , NMN has curative effect on animal heart failure
In November 2017 , NMN can effectively reduce the complications caused by the treatment of cerebral vascular embolism in animals
In August 2017 , NMN/Nicotinamide Riboside can effectively reduce the aging caused by animal muscle metabolism
August 2017 NMN can effectively protect animals from acute kidney injury
In July 2017 , NMN has curative effect on animal large intestine degeneration
In July 2017 , NMN can effectively improve the heart function of animals with cardiomyopathy
April 2017 NMN can effectively reduce cerebral edema and brain cell death in animals with hemorrhagic stroke
In April 2017 , NMN can effectively improve various pathological effects of animal cognitive impairment ( commonly known as Alzheimer's disease )
In March 2017 , NMN can effectively protect animals from retinopathy
December 2016 NMN can effectively improve the physical fitness, metabolism and vision of animals when they are old, and can reduce body weight, blood lipids and diabetes
In November 2016 , NMN can strongly protect animals from the damage caused by focal cerebral ischemia
In August 2016 , NMN can effectively improve various metabolic indicators of obese animals, and the effect is comparable to that of exercise
In July 2016 , NMN has a good effect on animal cognitive impairment ( dementia )
In June 2016 , NMN can reverse vascular aging in animals
In July 2014 , NMN has curative effect on Parkinson's disease in animals
In June 2014 , NMN has a protective effect on animal heart ischemia
October 2011 NMN can effectively improve type 2 diabetes induced by old age or diet in animals
